A modern view on the mechanism of occurrence and development of latent tuberculosis infection. Literature review

Сonsider the modern concept of understanding latent tuberculosis infection. To conduct this review, 64 literature sources were analyzed using electronic databases medical publications, mainly PubMed.About a quarter world's population is infected with M. tuberculosis. Most those are able to contain tuberculosis, that is, they in state infection without any manifestations active disease. At present stage, it impossible detect persistent (latent) which makes identify individuals who among likely and asymptomatic hosts cleared remain latently or will progress failure control eventually develop The dogma binary nature (active infection) an oversimplified now outdated concept. Understanding all immune components responses essence resistance it, constant even their elimination from host crucial for protective immunity tuberculosis.Studies response people resistant may provide insight into alternative mechanisms protection against treatment approaches vaccine development.